By Philip N Patsalos
Antiepileptic Drug Interactions: A medical consultant, moment Edition offers a pocket-sized, systematic description of the main clinically proper drug interactions that happen among AEDs and in addition among AEDs and non-AEDs. AEDs are awarded alphabetically and via drug category in 3 sections for simple entry: Drug interactions among AEDs; Drug interactions among AEDs and non-AEDs: Interactions affecting AEDs; and Drug interactions among AEDs and non-AEDs: Interactions laid low with AEDs.
Antiepileptic Drug Interactions: A scientific consultant, moment Edition might help physicians make extra rational offerings whilst polytherapy regimens are indicated and may be of curiosity to all who deal with sufferers with epilepsy: neurologists and neurosurgeons, trainees in any respect degrees, normal practitioners and epilepsy nurse specialists.
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Extra info for Antiepileptic Drug Interactions: A Clinical Guide
CNS Drugs. 2008;22:27–47. 9. Patsalos PN, Bourgeois BFD. The epilepsy prescriber’s guide to antiepileptic drugs. Cambridge: Cambridge University Press; 2010. 10. Reutens DC, Duncan JS, Patsalos PN. Disabling tremor after lamotrigine with sodium valproate. Lancet. 1993;342:185–6. 11. Rowan AJ, Meijer JW, de Beer-Pawlikowski N, van der Geest P, Meinardi H. Valproate-ethosuximide combination therapy for refractory seizures. Arch Neurol. 1983;40:797–802. 12. Pisani F, Oteri G, Russo MF, Di Perri R, Perucca E, Richens A.
Because the activity of these isoenzymes is genetically determined, genetic polymorphism resulting in enzyme variants with higher, lower, or no activity, or even resulting in the absence of an isoenzyme can have a profound effect on the pharmacological expression of an interaction (vide infra). In relation to AEDs, those Introduction xxxvii polymorphisms that have clinical consequences relate primarily to CYP2C9 and CYP2C19. Epoxide Hydrolases Epoxide hydrolases are a family of enzymes whose function is to convert arene oxides to trans-dihydrodiols and simple epoxides to vicinal diols by hydration and consequently are involved in detoxification processes, although sometimes they are involved in bioactivation reactions .
Clozapine . . . . . . . . . . . . . . . . Chlorpromazine . . . . . . . . . . . . . Fluphenazine . . . . . . . . . . . . . . Haloperidol . . . . . . . . . . . . . . . Olanzapine . . . . . . . . . . . . . . . Quetiapine . . . . . . . . . . . . . . . Risperidone . . . . . . . . . . . . . . . Thioridazine . . . . . . . . . . . . . . . Trazodone . . . . . . . . . . . . . .
Antiepileptic Drug Interactions: A Clinical Guide by Philip N Patsalos