By Timothy John Hayes Clark
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Thus, those asthmatics with most severe airflow obstruction had the greatest rate of loss of lung function. Ulrik et al (1992) found that the horse-racing effect was confined to extrinsic asthmatics and was not present in intrinsic asthma, though the rate of decline depended on age in both types of disease. Individuals with COPD generally present with largely fixed airflow obstruction after their fifth decade. , 1987). Thick line, normal people; thin line, asthmatics; dashed line, asthmatic smokers.
1993), and there is considerable within-subject variability in bronchodilator response in asthma and COPD (Kerstjens et al, 1993). Nagai et al. (1995) performed a post-mortem study examining the factors that determine the degree of reversibility to bronchodilators in patients with COPD. Greater reversibility was positively associated with bronchial inflammation, and particularly the degree of eosinophilic inflammation. Reduced reversibility and more severe airflow obstruction were associated with more severe emphysematous change.
Thorax, 47,429-36. British Thoracic Society. (1997a) The British guidelines on asthma management. Thorax, 52(Suppl. 1), S2-S21. British Thoracic Society. (1997b) BTS Guidelines for the management of chronic obstructive pulmonary disease. Thorax, 52(Suppl. 5), S2-S28. Brown PJ, Greville HW, Finucane KE. (1984) Asthma and irreversible airflow obstruction. Thorax, 39, 131-6. Burney PGJ. (1993) Epidemiology. In: Asthma, 3rd edn. ClarkTJH, Godfrey S, LeeTH, eds. London: Chapman and Hall, pp. 254-308.
Asthma by Timothy John Hayes Clark