By Anthony N. Laskovski
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Extra resources for Biomedical Engineering, Trends in Materials Science
Wang et al. , 2006). 4 Gene delivery Chitosan possesses many of the properties required of gene therapy material. It is suitable as a base polymer for a nonviral DNA delivery system. It is important to realize that molecular weight is a critical factor in cytotoxicity. , 1999). For studying the relationship between structure and transfection efficiency five chitosans with molecular weights from 31 to 190 kDa were chosen. , 2001). , 2010). The maximum level was achieved for DP from 31 to 42. With increasing chain length, gene expression was lower and delayed.
Novel Chitin and Chitosan Materials in Wound Dressing 21 Kweon DK, Song SB, Park YY. Preparation of water-soluble chitosan/heparin complex and its application as wound healing accelerator. Biomaterials 2003; 24: 1595-1601. Lee YM, Kim SS, Park MH, Song KW, Sung YK, Kang IK. Beta-chitin-based wound dressing containing silver sulfurdiazine. J Mater Sci Mater Med 2000; 11: 817-823. Li LH, Deng JC, Deng HR, Liu ZL, Li XL. Preparation, characterization and antimicrobial activities of chitosan/Ag/ZnO blend films.
They found that introducing chitin nanofibres considerably increased the tensile strength of medium molecular weight (270 kDa) chitosan films, helping this complex to be a better accelerator of wound healing. This stands in agreement with results concerning the tensile strength and arrangement of collagen fibres in the skin, obtained previously by Cho et al. , 1999). They demonstrated the better efficacy of water-soluble chitin in wound healing in comparison to chitin and chitosan samples. 6 The hypocholesterolemic effect There are also studies concerning the role of chitosan in reducing the total cholesterol level, and the influence of molecular weight on this was tested.
Biomedical Engineering, Trends in Materials Science by Anthony N. Laskovski