By Asadolah Saadatniaki
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Additional resources for Clinical use of local anesthetics
The first or any of the repeated urethrotomies didn’t have a success that exceeded 9% (Santucci and Eisenberg, 2010). There was one randomized trial testing the efficacy of Mitomycin C application in internal urethrotomy, which showed its success in reducing the rate of recurrence of strictures (Mazdak, 2007). 3 Ureteroscopic stone fragmentation The ureter receives a rich autonomic nerve supply. Unmyelinated nerve fibers are located in the lamina propria, muscle coat, and adventitia of the ureter.
Reducing the pain due to tissue irritation The tissue irritation from local anesthetics is primarily due to the acidity of the anesthetic solution. The anesthetics are acidified to increase their solubility, as well as their chemical stability. To decrease irritation produced by local anesthetics, the solution may be buffered through several means: Mix lidocaine with adrenaline with plain lidocaine in equal part. 1mL). The subsequent solution is lidocaine with adrenaline, but at same pH as plain lidocaine.
Philadelphia: JB Lippincott, 1988:47–110.  Auletta MJ, Grekin RC. Local anesthesia for dermatologic surgery. New York: Churchill Livingstone, 1991:1–40. , Bombay: Popular Prakashan Pvt. Ltd. 1992; 189-194. 28 Clinical Use of Local Anesthetics  Covino BG, Vassallo HG. Local anesthetics: mechanisms of action and clinical use. New York: Grune & Stratton, 1976:1–148.  Dzubow LM. The interaction between propranolol and epinephrine as observed in patients undergoing Moh’s surgery. J Am Acad Dermatol 1986;15:71–5.
Clinical use of local anesthetics by Asadolah Saadatniaki