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Download e-book for iPad: Control Mechanisms of Drinking by J. T. Fitzsimons (auth.), G. Peters, J. T. Fitzsimons, L.

By J. T. Fitzsimons (auth.), G. Peters, J. T. Fitzsimons, L. Peters-Haefeli (eds.)

ISBN-10: 364261907X

ISBN-13: 9783642619076

ISBN-10: 3642619096

ISBN-13: 9783642619090

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Owing to the considerable variations in responses between different 31 dogs to the same rate of vasopressin infusion there was no consistent dose - response relationship in the whole group of animals. Nevertheless such a relationship could be demonstrated in individual dogs (Fig. 12 b). 05:p (0011 I r~::~_-_ -' __ 'P( Ol! c- - -- - - - - - ~ , - - NS- , Fig. 12 a. Effect of vasopressin infused into the lateral cerebral ventricle of the dog on intracellular thirst threshold. 0 ... 0 E-<"O OL--------------------- Fig.

E. n Plasma sodium concentration PNa m-equiv/l. E. E. 2 67 Table 2. Threshold cellular dehydration (r % Vi) producing drinking response during infusions of equiosmolar solutions of NaCl and mannitol. E. E. ) and sodium load (Na: m-equiv) in WOLF'S original equations. The data demonstrate that both solutions induced the dogs to drink at precisely the same threshold cellular dehydration. In our experience, assessing the osmotic reactivity of the thirst mechanism by measuring the threshold cellular dehydration is a reliable experimental method.

It is worth noting that, in all dogs but one, there was a close relationship between these two values. These results suggest that after haemorrhage activation of thirst and the hypothalamohypophysial antidiuretic system restore the body water by increasing the water intake and decreasing the rate of elimination. In summary (Fig. 15): we suggest that two interdependent systems, operating on intake and excretion, are primarily involved in the control of body fluid volume, particularly of the circulating blood volume.

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Control Mechanisms of Drinking by J. T. Fitzsimons (auth.), G. Peters, J. T. Fitzsimons, L. Peters-Haefeli (eds.)


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